Cholesteryl Ester Transfer Protein (CETP) Deficiency and CETP Inhibitors
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منابع مشابه
Cholesteryl Ester Transfer Protein (CETP) Deficiency and CETP Inhibitors
Epidemiologic studies have shown that low-density lipoprotein cholesterol (LDL-C) is a strong risk factor, whilst high-density lipoprotein cholesterol (HDL-C) reduces the risk of coronary heart disease (CHD). Therefore, strategies to manage dyslipidemia in an effort to prevent or treat CHD have primarily attempted at decreasing LDL-C and raising HDL-C levels. Cholesteryl ester transfer protein ...
متن کاملCholesteryl ester transfer protein (CETP) inhibitors: is there life after torcetrapib?
Despite tremendous progress made in the management of CHD, a significant number of fatal and nonfatal CHD events still occur, which leads researchers to target other modifiable risk factors for CHD including low HDL-c (high density lipoprotein cholesterol). Although the torcetrapib experience was a major blow to CETP inhibition and indeed to the entire field of HDL-targeted therapeutics, it was...
متن کاملIs cholesteryl ester transfer protein (CETP) deficiency atherogenic in familial hypercholesterolemia.
Atherosclerosis is considered to be caused by many risk factors. Epidemiological studies have shownthat the co-existence of multiple risk factors contributes to the progress in the disease more heavily than a single risk factor. A high level of LDLis a very strong risk factor for coronary heart disease (CHD), showing the high incidence of angina or myocardial infarction in familial hypercholest...
متن کاملApolipoprotein CI overexpression is not a relevant strategy to block cholesteryl ester transfer protein (CETP) activity in CETP transgenic mice.
ApoCI (apolipoprotein CI) is a potent inhibitor of plasma CETP [CE (cholesteryl ester) transfer protein]. The relevance of apoCI overexpression as a method for CETP blockade in vivo was addressed in the present study in CETPTg/apoCITg mice (mice expressing both human CETP and apoCI). Despite a significant reduction in specific CETP activity in CETPTg/apoCITg mice compared with CETPTg mice [tran...
متن کاملCholesteryl ester transfer protein (CETP) increases postprandial triglyceridaemia and delays triacylglycerol plasma clearance in transgenic mice.
The CETP (cholesteryl ester transfer protein) is a plasma protein synthesized in several tissues, mainly in the liver; CETP reduces plasma HDL (high-density lipoprotein) cholesterol and increases the risk of atherosclerosis. The effect of CETP levels on postprandial intravascular metabolism of TAGs (triacylglycerols) is an often-overlooked aspect of the relationship between CETP and lipoprotein...
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ژورنال
عنوان ژورنال: Molecules and Cells
سال: 2014
ISSN: 1016-8478,0219-1032
DOI: 10.14348/molcells.2014.0265